We increasingly live in a data-driven, web-enabled, supercomputer-powered, globally interconnected world, and this poses significant new challenges to scientists and engineers throughout all of their disciplines. Attacking these problems will require significant new technologies for sensing the environment, collecting and analyzing this data, using it to simulate engineered, biological and social systems, and applying these results to provide effectors, physical or cyber, that can help solve critical global challenges. The Computational Science and Engineering thrust focuses on developing such technologies as well as further enabling them through development of critical computational methodologies including data-intensive supercomputing, large-scale agent-based simulation, and cognitive computing technologies.