We promote collaborative research involving the integration of modeling, optimization, and computation to solve complex problems emerging in science and engineering. The key to understanding the multifaceted and multidisciplinary aspects of these problems, and to creating new solution strategies, is the development, analysis, and simulation of mathematical models. Designed to establish new modes of operation for applied mathematicians, scientists, and engineers by cutting across the boundaries of traditional approaches, our Center provides new avenues of research and collaboration.